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50 months ago
Farewell to Sciblogs
There exists a sustained brouhaha around the nature of the placebos used in the clinical trials for Gardasil. The notion that some of the most rigorous vaccine trials ever conducted are questionable on account of their well thought out placebos is ill conceived at best. This is after over 270 million doses and huge epidemiological studies from all over the world comparing outcomes in vaccinated and unvaccinated (discussed ad nausea in my previous blogs). Guess what! Vaccinated have better outcomes than unvaccinated. Anyway, for the sake of anyone who is wondering about what all the placebo ruckus is about I have attempted to explain below. What is a placebo? A clinical placebo is a treatment that has no intended therapeutic effect. In a clinical trial a placebo could be a saline formulation which is typically inert when injected. Or, the placebo could be the formulated mix of salts and left over impurities that are present with the vaccine under investigation minus the active ingredient (vaccine). Vaccines often also have an extra added ingredient, called the adjuvant, which works as an immune enhancer. The adjuvant is sometimes included in the placebo formulation. Mind over matter is a very real phenomenon …
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